Sorry, you need to enable JavaScript to visit this website.

PFIZERPEN® (penicillin G potassium) Indications and Usage



Penicillin G Potassium for Injection, USP is indicated in the treatment of serious infections caused by susceptible strains of the designated microorganisms in the conditions listed below.

Appropriate culture and susceptibility tests should be done before treatment in order to isolate and identify organisms causing infection and to determine their susceptibility to penicillin G.

Therapy with Penicillin G Potassium for Injection, USP may be initiated before results of such tests are known when there is reason to believe the infection may involve any of the organisms listed below; however, once these results become available, appropriate therapy should be continued.

Septicemia, empyema, pneumonia, pericarditis, endocarditis, meningitisStreptococcus pyogenes (group A β-hemolytic streptococcus), other β-hemolytic streptococci including groups C, H, G, L and M, Streptococcus pneumoniae and Staphylococcus species (non-penicillinase producing strains)
AnthraxBacillus anthracis
Actinomycosis (cervico-facial disease and thoracic and abdominal disease)Actinomyces israelii

Botulism (adjunctive therapy to antitoxin), gas gangrene, and tetanus (adjunctive therapy to human tetanus immune globulin)
Clostridium species
Diphtheria (adjunctive therapy to antitoxin and prevention of the carrier state)
Corynebacterium diphtheriae
Erysipelothrix endocarditis
Erysipelothrix rhusiopathiae
Fusospirochetosis (severe infections of the oropharynx [Vincent's], lower respiratory tract and genital area)
Fusobacterium species and spirochetes
Listeria infections including meningitis and endocarditis
Listeria monocytogenes
Pasteurella infections including bacteremia and meningitis
Pasteurella multocida
Haverhill feverStreptobacillus moniliformis
Rat bite feverSpirillum minus or Streptobacillus moniliformis
Disseminated gonococcal infectionsNeisseria gonorrhoeae (Penicillin-susceptible)
Syphillis (congenital and neurosyphilis)Treponema pallidum
Meningococcal meningitis and/or septicemiaNeisseria meningitidis
Gram-negative bacillary infections (bacteremias)
Penicillin G is not the drug of choice in the treatment of Gram-negative bacillary infections.
Gram-negative bacillary organisms (i.e. Enterobacteriaceae)

To reduce the development of drug-resistant bacteria and maintain effectiveness of Penicillin G Potassium and other antibacterial drugs, Penicillin G Potassium should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Did you find an answer to your question? Yes No
Did you find an answer to your question? Yes No